Aloe vera L. high molecular weight fractions (AHM) containing less than 10 ppm of barbaloin and polysaccharide (MW: 1000 kDa) with glycoprotein, verectin (MW: 29 kDa), were prepared by patented hyper-dry system in combination of freeze–dry technique with microwave and far infrared radiation. AHM produced significant decrease in blood glucose level sustained for 6 weeks of the start of the study. Significant decrease in triglycerides was only observed 4 weeks after treatment and continued thereafter. No deterious effects on kidney and liver functions were apparent. Treatment of diabetic patients with AHM may relief vascular complications probably via activation of immune system.

Type 2 Diabetes Mellitus (T2DM) is one of the primary threats to human health due to its increasing prevalence, chronic course and disabling complications. Synthetic hypoglycemic drugs cannot fully control blood glucose level as well as cause side effects prompting the patients stop taking the medication. Aloe vera is a widely distributed Liliaceae plant in tropical regions and cosmetic and medicinal products are made from the mucilaginous tissue in the centre of the A. vera called A. vera gel. The peripheral bundle of sheath cells produce intensely bitter, yellow latex, commonly termed aloe juice, or sap or aloes. Unlike aloes, A. vera gel contains no anthraquinones, which are responsible for the strong laxative effects of aloe.

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